Characterization of Plasma Protein Alterations in Pregnant and Postpartum Individuals Living With HIV to Support Physiologically-Based Pharmacokinetic Model Development

Our analysis, published in Frontiers in Pediatrics, developed computational functions to describe how two plasma proteins (albumin and alpha-1-acid glycoprotein) change over the course of pregnancy and the postpartum period. As plasma-protein drug binding represents critical modifier of drug PK, an understanding how these proteins change in different populations is critical for the development of life-stage specific PBPK models. Our developed computational functions were created using open-source software (i.e., R) and can readily be integrated into models developed by other researchers.