Characterization of Plasma Protein Alterations in Pregnant and Postpartum Individuals Living With HIV to Support Physiologically-Based Pharmacokinetic Model Development

In this work, we employed generalized additive modeling to describe changes albumin and alpha-1-acid glycoprotein concentrations in pregnant and postpartum individuals living with HIV. _Front Pediatr. 2021 Oct 13;9:721059_

Simulated Assessment of Pharmacokinetically Guided Dosing for Investigational Treatments of Pediatric Patients With Coronavirus Disease 2019

We report the results of a model-based analysis indicating hydroxychloroquine lung concentrations may be too low to exert an antiviral effect for treatment of COVID-19 in children and adults. _JAMA Pediatr. 2020;174(10):e202422_

Population pharmacokinetics of olanzapine in children

In this study, we evaluated the pharmacokinetics of the atypical antipsychotic olanzapine in children, from infants to adolescents. Based on our analysis, we developed preliminary dosing recommendations for children. _Br J Clin Pharmacol. 2020 Jun 4_

Dosing of Continuous Fentanyl Infusions in Obese Children: A Population Pharmacokinetic Analysis

We examined the pharmacokinetics of the opioid analgesic fentanyl in a cohort of 32 children, the majority of whom were obese. We utilized a novel probability-based strategy to optimize dosing of continuous fentanyl infusions in obese children. _J Clin Pharmacol. 2019 Dec 8;10.1002/jcph.1562_